Document Type: Original Article
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Background and aims: Infectious diarrhea with Salmonella spp. is the most significant cause of morbidity and mortality in neonatal calves that need emergency treatment. Trans-cinnamaldehyde (TC) is among the secondary metabolites of cinnamon trees that can be used as antimicrobial agents. The aim of the present study was to evaluate antibacterial activity of Trans-cinnamaldehyde on Salmonella enterica isolated from calf diarrhea.
Methods: 150 stool specimens were collected from the calves refereed to veterinary hospital and clinic of Urmia University during the period of winter to spring, 2018. Then, Salmonella enterica was isolated by culture and confirmed by molecular method. Antimicrobial activity was determined by agar disk diffusion method.
Results: The results of disk diffusion test showed that the Trans-cinnamaldehyde has an antibacterial effect against Salmonella enterica, with a diameter of the inhibition zone of 23 mm, which was very effective compared with the diameter of the inhibition zone caused by standard antimicrobial agents such as gentamicin and chloramphenicol that were 13.1 and 14 mm in the inhibition zone, respectively.
Conclusion: The results of this study indicate that cinnamaldehyde has antibacterial properties and can be used as a cheap, safe, and available source for therapeutic use in Salmonella enterica-induced bacterial infections.