Antifungal effects of the extracts of the shallots and artichokes on Candida albicans

Document Type: Original Article

Authors

1 Department of Food Sciences, University of Zabol

2 Associate Professor, Department of plant Breeding and Biotechnology, faculty of Agriculture; University of Zabol

3 Instructor, Center of Agricultural Biotechnology, University of Zabol

Abstract

Background and aims: Over the recent decades, the infections caused by the opportunistic fungus including the Candida albicans (C. albicans) have increased, thereby causing the high rate of diseases. With respect to the limitations of the treatment of the fungal infections and expensive antifungal drugs, researchers have been increasingly interested in finding anti-fungal drugs. This study aims to investigate the antifungal effects of the extracts of the shallots and artichokes on C. albicans.
Methods: In this experimental research, the extracts of the shallot and artichoke were prepared using a rotary device. The inhibitory concentration against C. albicans was determined using incubation in media.
Results: The results of the study showed that increased concentration of the extract increased the antifungal effects. The extract of the artichoke had higher inhibitory effect compared to the extract of the shallot. Moreover, as the extract was decreased the size of the fungi colony was increased.
Conclusion: The results of the study showed that extracts of the shallots and artichoke were proper inhibitors for the C. albicans and it is hoped that herbal medicines and possibly new compounds for treatment of the fungal infections be discovered in future.

Keywords

Main Subjects


1. Riordan T, Macaulay ME, James JM, Leventhall PA, Morris EM, Neal BR, et al. A prospective study of genital infections in a family-planning clinic. 1. Microbiological findings and their association with vaginal symptoms. Epidemiol Infect. 1990; 104(1): 47-53.

2. Dalle F, Franco N, Lopez J, Vagner O, Caillot D, Chavanet P, et al. Comparative genotyping of Candida albicans bloodstream and nonbloodstream isolates at a polymorphic microsatellite locus. J Clin Microbiol. 2000; 38(12): 4554-9.

3. Karahan ZC, Guriz H, Agirbasli H, Balaban N, Gocmen JS, Aysev D, et al. Genotype distribution of Candida albicans isolates by 25S intron analysis with regard to invasiveness. Mycoses. 2004; 47(11-12): 465-9.

4. Goswami D, Goswami R, Banerjee U, Dadhwal V, Miglani S, Lattif AA, et al. Pattern of Candida species isolated from patients with diabetes mellitus and vulvovaginal candidiasis and their response to single dose oral fluconazole therapy. J Infect. 2006; 52(2): 111-7.

5. Grigoriou O, Baka S, Makrakis E, Hassiakos D, Kapparos G, Kouskouni E. Prevalence of clinical vaginal candidiasis in a university hospital and possible risk factors. Eur J Obstet Gynecol Reprod Biol. 2006; 126(1): 121-5.

6. Esmaeilzadeh S, Omran SM, Rahmani Z. Frequency and etiology of vulvovaginal candidiasis in women referred to a gynecological center in Babol, Iran. Int J Fertil Steril. 2009; 3(2): 74-7.

7. Khoramdel S. The effect of biological nitrogen and phosphorus fertilizers on quantitative specifications of Nigella Sativa L. [Master Thesis]. Agriculture Faculty of Agriculture, Ferdowsi University of Mashhad; 2008.

8. Avato P, Tursil E, Vitali C, Miccolis V, Candido V. Allylsulfide constituents of garlic volatile oil as antimicrobial agents. Phytomedicine. 2000; 7(3): 239-43.

9. Bianchini F, Vainio H. Allium vegetables and organosulfur compounds: Do they help prevent cancer? Environ Health Persp. 2001; 109(9): 893.

10. Sepahvand A. Investigation of Morphologic Variety of the Different Accessions of Shallots in Lorestan Province. World Res J Med Aromat Plant. 2008; 24: 109-16.

11. Otang WM, Grierson DS, Ndip RN. Antifungal activity of Arctotis arctotoides (L.f.) O. Hoffm. and Gasteria bicolor Haw. against opportunistic fungi associated with human immunodeficiency virus/acquired immunodeficiency syndrome. Pharmacogn Mag. 2012; 8(30): 135-40.

12. Falahati M. Fateh R. Sharifinia S. Effects of anti-candida of the shallot on the chronic candidiasis. Razi J Med Sci. 2002; 100(1): 19.

13. Mahmoudabadi AZ, Nasery MG.
Anti-fungal activity of shallot, Allium ascalonicum Linn. (Liliaceae), in vitro. J Med Plants Res. 2009; 3(5): 450-3.

14. Dalirsani Z, Adibpour M, Aghazadeh M, Amirchaghmaghi M, Falaki F, Hamzei F. In Vitro Comparison of Inhibitory Activity of 10 Plant Extracts against Candida Albicans. Aust J Basic Appl Sci. 2011; 5(5): 930-5.

15. Naganawa R, Iwata N, Ishikawa K,
Fukuda H, Fujino T, Suzuki A. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic. Appl Environ Microbiol. 1996; 62(11): 4238-42.

16. Arbabian S. Akhondzade DM, Sepahi A, Chalabian F. Antimicrobial Effects of Ethanolic, Aqueous and Acetonic Extracts of the Cynara Scolymus (Artichoke) on Some Bacteria and Fungi. J Knowl Microbiol. 2009; 4(1): 21-8.